Specifically, the expression of Wwtr1 (TAZ) gene was significantly upregulated in fresh dendritic cells isolated on 50 kPa hydrogel compared with fresh dendritic cells isolated on 2 kPa hydrogel; therefore, TAZ can enter the nucleus more easily under mechanical stress and exert transcriptional regulatory effects on downstream tumor-promoting genes. Here, WWTR1 is linked to neoplasm.