IFNA1 and infection: To evaluate the protective efficacy of IFN in mice infected with rHEP, we next examined the pathogenicity of rRABV in AG129 mice: type-I/II IFN receptor-knockout (KO) mice in an S129 background, which are highly susceptible to infection by various viruses (Aliota et al., 2016; Milligan et al., 2017; Tan et al., 2010).