Finally, to further investigate the relationship between the IFN responses and pathogenicity of the rRABVs, we compared IFN inducibility and the sensitivity of rRABVs under an IFN-mediated antiviral state using a human neuroblastoma cell line SYM-I, in which IFN signaling pathways are validated (Honda et al., 1984). This evidence concerns the gene IFNA1 and neuroblastoma.