This hypothesis was partially confirmed by the report that down-regulation of GAS5 rescued leukemic T cells from rapamycin, an mTOR antagonist.82 As SNORD44 is highly conserved in GAS5, it has been suggested to be a significant functional component of the GAS5 gene,21 which is consistent with a study reporting that it shares a similar function with GAS5.70 Together, these findings suggest that SNORD44 may be involved in rapamycin drug resistance in leukemia. The gene discussed is GAS5; the disease is leukemia.