GAS5, a multi-small-nucleolar-RNA host gene, regulates apoptosis and the growth arrest of T cells,70 and its downregulation promoted Friend leukemia.72 Interestingly, SNORD44, an intronic snoRNA in GAS5, was reported to regulate apoptosis and growth arrest in breast cancer.21 Because apoptosis failure is tightly associated with drug resistance in cancer,21 GAS5 and SNORD44 may play essential roles in drug resistance. The gene discussed is GAS5; the disease is cancer.