Although relevant research in leukemia is limited, the evidence that snoRNAs function in drug resistance has been reported in other human cancers.24 For example, the expression of the H/ACA box snoRNA ACA11 in MM.1S cells reduced the level of ROS and increased resistance to doxorubicin, suggesting that ACA11 rescues cells from cytotoxic chemotherapy (Table 1).24 Indeed, snoRNAs have become promising targets for treatment in drug-resistant leukemia. Here, SCARNA22 is linked to leukemia.