In the PLC-γ2 pathway, if PLC-γ2 lacks the autoinhibitory C-terminal Src homology 2 (cSH2) domain, PLC-γ2 associated antibody deficiency and immune dysregulation (PLAID) will occur.22 The possible reason is that the cSH2 structure of PLC-γ2 can stabilize the early signaling complex of BCR cross-linking. This evidence concerns the gene PLCG2 and agammaglobulinemia.