Although the exact pathophysiological relationship between hyponatremia and severe inflammation is yet to be elucidated, several studies have demonstrated that the development of hyponatremia in severe inflammation cases is a process which probably involves proinflammatory cytokines such as interleukin- (IL-) 1β and IL-6 as well as antidiuretic hormone (ADH) secretion [14, 15]. Here, IL6 is linked to Hyponatremia.