In a quest to find the modulators of the EMT, we performed a repositioning screen using an FGFR2-based splicing reporter and obtained three compounds that are able to (1) induce the expression of epithelial markers in PCa cells and (2) switch FGFR2 splicing from exon IIIc (9) inclusion, which is associates with aggressive cancer behavior, to exon IIIb (8), which is therapeutically beneficial. Here, FGFR2 is linked to cancer.