In this study, we firstly explored the prognostic value of the whole ARID members and found that the expressions of JARID2, ARID5B, ARID5A, ARID3C, ARID3B, ARID3A, ARID2, ARID1B, and ARID1A were related to overall survival and progression-free survival of HCC patients. The gene discussed is ARID3B; the disease is hepatocellular carcinoma.