A four-gene signature (CENPA, SPP1, MAGEB6, and HOXD9) and a six-gene signature (GLS, SRXN1, SMG5, VNN2, AHSA1, and SQSTM1) were demonstrated to show an important value in predicting the total survivals of HCC patients [31, 32]. The gene discussed is SPP1; the disease is hepatocellular carcinoma.