TNNI3 and ischemia: The researchers noted that the degree of proteolytic cleavage of cardiac troponin I increases with an increase in the severity of ischemia and myocardial injury: the highest degree of proteolytic cleavage of cardiac troponin I was characteristic of patients with ST-segment elevation myocardial infarction, while in patients with non-ST-segment elevation myocardial infarction the degree of troponin I degradation was significantly lower.