CRP and atherosclerosis: However, the evidence concerning the net effect of CRP on initiation and progression of atherosclerosis is still lacking (44) leading over to (3) with excessive tissue-stranded modified lipoprotein during atherogenesis being a prime example of the misguided nutritional culture of the most highly evolved primate Homo sapiens with subsequent either beneficial or harmful (still to be clarified) participation of innate immunity with CRP as an important component (see below).