In terms of mechanisms of action by which PPARG polymorphisms influence on the susceptibility to CAD, the first thing that comes to mind is that polymorphisms in PPARG lead to abnormal expression of this gene and/or dysfunction of PPARγ protein, resulting in aberrant expressions of PPARγ-targeted genes, metabolic disorders, and arteriosclerotic cardiovascular disease (Figure 2). This evidence concerns the gene PPARG and Other metabolic disease.