Being activated by endogenous and exogenous ligands, PPARγ works in concert with retinoid X receptor (RXR) and is able to increase the insulin sensitivity, (24) promote adipocyte differentiation, (25) and stimulate adipogenesis, (26) and has the properties of anti-atherosclerosis, (27, 28) anti-inflammation, (27, 28) and anti-oxidation (29). Here, INS is linked to atherosclerosis.