Relationships of several rare variants in PPARG such as c.25924C > T and c.26233T > A in PPARγ3 promoter, and c.93640T > C, c.93673T > C, and c.93695C > T in PPARγ4 promoter to CAD were explored in an Italian population, and the explorers found that the c.93695C > T polymorphism was significantly correlated with acute coronary syndrome (ACS); T allele conferred a protective effect against ACS at both univariate (OR, 0.45; 95% CI, 0.29–0.69; p < 0.001) and multivariate (OR, 0.44; 95% CI, 0.25–0.76; p < 0.01) analyses (40). The gene discussed is PPARG; the disease is coronary artery disorder.