Kaplan–Meier survival analyses showed that high-risk patients had remarkably reduced OS compared with low-risk patients in the TCGA-LIHC dataset, even if confounding factors (age, TNM stage, histologic grade, Child–Pugh grade, vascular invasion, AFP, and residual tumor status after surgery) were adjusted after PSM analysis (Figures 6A,B). This evidence concerns the gene AFP and neoplasm.