Taken together, as the uptake of EVs, which promote V30M-TTR aggregation, into cells was increased by the complex of V30M-TTR and EVs (Figures 4A–C), increased EVs levels in ATTRv amyloidosis could enhance tissue deposition of TTR aggregates, which follows a decrease of TTR aggregates in the serum of patients with ATTRv amyloidosis (Figure 5C). Here, TTR is linked to familial amyloid neuropathy.