With regard to Alzheimer’s disease in amyloidosis with dementia, reduced TTR levels have been detected in both the cerebrospinal fluid and plasma of patients with Alzheimer’s disease (Han et al., 2011; Saponaro et al., 2020) and in subjects with mild cognitive impairment, becoming more pronounced as the disease progresses. The gene discussed is TTR; the disease is early-onset autosomal dominant Alzheimer disease.