It was revealed that pretreatment of U373 MG human glioma cells with ER inducers, TM or TG, high expressions of HSP27, and αB-crystallin were induced, and the phosphorylation of HSP27 was upregulated by mediating activation of the p38 MAP kinase pathway (Ito et al., 2005). Here, HSPB1 is linked to glioma.