It was revealed that pretreatment of U373 MG human glioma cells with ER inducers, TM or TG, high expressions of HSP27, and αB-crystallin were induced, and the phosphorylation of HSP27 was upregulated by mediating activation of the p38 MAP kinase pathway (Ito et al., 2005). Here, HSPB1 is linked to central nervous system cancer.