The annotated IL-17 signaling pathway generated with IPA (Figure 5B) contains downstream signaling pathways (MAPK and NFkB) that stimulate expression of cytokines that induce IL-17 production by γδT cells, as well as IL-17 inducible mediators (e.g., matrix metalloproteases, SPRR2) that are involved in the development of the cornea and conjunctival epithelial disease of dry eye. This evidence concerns the gene NFKB1 and dry eye syndrome.