NFKB1 and Keratoconjunctivitis sicca: The annotated IL-17 signaling pathway generated with IPA (Figure 5B) contains downstream signaling pathways (MAPK and NFkB) that stimulate expression of cytokines that induce IL-17 production by γδT cells, as well as IL-17 inducible mediators (e.g., matrix metalloproteases, SPRR2) that are involved in the development of the cornea and conjunctival epithelial disease of dry eye.