MAPT and early-onset autosomal dominant Alzheimer disease: Single-cell transcriptomic profiling of aging and Alzheimer’s disease combined with data from amyloid and tau PET, [18F]FDG PET, and rs-Fmri, and structural MRI to unveil the gene and macroscopic factor interactions and the biological mechanisms underlying Alzheimer’s disease (148) (Figures 2A–E).