According to the criteria of the GRADE guideline, there was one high-quality evidence, Dai et al. (44) conducted a meta-analysis and reported that the HE4 level can provide a useful prognostic biomarker (only for DFS) for patients with cancers (987 patients with EC, 211 patients with LC, and 98 patients with OC). The gene discussed is WFDC2; the disease is laryngotracheoesophageal cleft.