GHR fl/d3 dominant model had positive multiplicative interactions on pre-hypertension and hypertension (interactive ORs [95% CIs]: 1.735 [1.214-2.481], P = 0.003; 1.509 [1.092-2.086], P = 0.013; Supplementary Tables 5, 6). The gene discussed is GHR; the disease is Hypertension.