We found that the downstream genes TRAF6 and IKKβ were significantly upregulated in renal tissues throughout the experiment, and the expression trend of TLR7 was the same; however, the increase in TRAF6 was not obvious in the later stage, suggesting that SX9 inhibited the expression of TRAF6 in the later stage of kidney infection. This evidence concerns the gene TRAF6 and pyelonephritis.