A methylation panel of ANKRD18CP and EPB41L3 genes has relatively low sensitivity to detect CIN2+ in women with age <30 years (55), consistent with other methylation tests involving DLX1, ITGA4, RXFP3, SOX17, and ZNF671 genes (56), or FAM19A4 (43), while low methylation rates have been observed in young women with CIN. This evidence concerns the gene RXFP3 and cervical squamous intraepithelial neoplasia.