A meta-analysis has validated that increased methylation at the promoters of several genes (CADM1, MAL, miR-124-2, FAM19A4, POU4F3, EPB41L3, PAX1, and SOX1) and HPV16 L1/L2 correlates to CIN lesion, with good performance in the triage of advanced CIN (20). The gene discussed is MAL; the disease is cervical squamous intraepithelial neoplasia.