There was no significant difference in curative effects and toxic reactions between the two radioactive ligands, but the average absorbed dose of 177Lu-PSMA-I&T is lower than that of 177Lu-PSMA-617 in lacrimal gland, which rarely causes symptoms of lacrimal gland dysfunction such as dry eyes and blurred vision (19). This evidence concerns the gene FOLH1 and Keratoconjunctivitis sicca.