PDF and neoplasm: The ‘NU-like’ IUP signatures included upregulation of proteins related to tumor-suppressive functions, namely, SELENBP1, OGDH, CKB, and GOT1 (45–48), besides downregulation of proteins related to oncogenic property, such as TOP2B, NOC2L, PSMD14, SRP68, CYP4F11, PDF, MCU, and HSPD1 (48–54).