The ‘NU-like’ IUP signatures included upregulation of proteins related to tumor-suppressive functions, namely, SELENBP1, OGDH, CKB, and GOT1 (45–48), besides downregulation of proteins related to oncogenic property, such as TOP2B, NOC2L, PSMD14, SRP68, CYP4F11, PDF, MCU, and HSPD1 (48–54). The gene discussed is CKB; the disease is neoplasm.