On the contrary, the ‘PUC-like’ IUP signatures prioritized proteins previously implicated in cancer promotion, including enrichment of oncogenes [CIT, GPAA1, SRRM2, SETD3, TWF1, and MRPS23 (55–60)] and low expression of tumor-suppressor proteins [SHPRH and ADD3 (61, 62)]. This evidence concerns the gene SETD3 and cancer.