AKT1 and gastric cancer: found that lncRNA can be used as a new regulator of autophagy, and the up-regulated lncRNA MALAT1 in GC tissues can lead to the overexpression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), which leads to autophagy inhibition and increased IL-6 expression, thereby activating the AKT/mTOR pathway and ultimately leading to the progression of GC (120).