However, the peak elevations of these markers were significantly higher in patients with Grade 4 or 5 CRS (Ferritin median 130,000ng/mL, range, 11,200-299,000 and CRP median 22.9mg/dL, range 16.0-37.1) than in those with Grade 0-3 CRS (Ferritin median 8,290ng/mL; range, 280-411,936 and CRP 16.2; range, 0.7-56.5). This evidence concerns the gene CRP and congenital rubella syndrome.