Furthermore, a peak in cytokine levels on a 24-cytokine profile including, IFNγ, IL6, IL8, sIL2Rα, sgp130, sIL6R, MCP1, MIP1α, MIP1β and GM-CSF during the first month after CART cell infusion was associated with Grade 4-5 CRS compared with Grade 0-3 CRS. This evidence concerns the gene IL6ST and congenital rubella syndrome.