Moreover, based on the cbioportal database, the missense mutation of GPX8 has been found as the main type of genetic alteration, and S61Y/F alteration was the important site, which was detected in 2 cases of COAD, 1 case of BLCA and 1 case of UCEC (Figure 4C). Here, GPX8 is linked to bladder transitional cell carcinoma.