By searching in the Oncomine, the expression level of the GPX8 gene was found significantly up-regulated in many types of cancers, including BRCA (Breast invasive carcinoma), CHOL(Cholangiocarcinoma), COAD (Colon adenocarcinoma), GBM(Glioblastoma multiforme), HNSC(Head and Neck squamous cell carcinoma), KIRC(Kidney renal clear cell carcinoma), KIRP(Kidney renal papillary cell carcinoma), LIHC(Liver hepatocellular carcinoma), LUAD(Lung adenocarcinoma), LUSC(Lung squamous cell carcinoma), STAD(Stomach adenocarcinoma) (Figures 1A, B). This evidence concerns the gene GPX8 and head and neck squamous cell carcinoma.