Chemotherapy treatment induced splenomegaly (Figure 4A, t7 = 5.81, p = 0.0007), increased circulating inflammatory proteins including TNFα (Figure 4B, χ2 = 8.22, p = 0.004), IFNγ (Figure 4C, t6 = 2.34, p = 0.06), IL-6 (Figure 4D, χ2 = 6.91, p = 0.009), IL-2 (Figure 4E, χ2 = 9.41, p = 0.002), IL-1β (Figure 4F, χ2 = 3.77, p = 0.05), CXCL1 (Figure 4G, t9 = 2.89, p = 0.02), and increased the anti-inflammatory protein IL-10 (Figure 4H, χ2 = 5.44, p = 0.02). Here, IFNG is linked to Splenomegaly.