BRD4 and cancer: In colorectal cancer (CRC), interleukin-6/8 (IL-6/8-JAK2), the matrix signal activated by cancer-associated fibroblasts (CAFs), induces phosphorylation of BRD4 at tyrosine 97/98 (Y97/98), which is stable due to its interaction with the deubiquitinase UCHL3 (62).