BRD4 and neoplasm: Further research shows that under the stimulation of inflammatory signals in the tumor microenvironment, the phosphorylation of BRD4 at Y97/98 promotes the interaction with STAT3 and regulates carcinogenic enhancers such as MYC, CXCL1 and CXCL2 to induce chromatin remodeling and promote the transcriptional program (62).