According to the current research results, we have to ask the following questions: what type of relationship exists between BRD4 phosphorylated by relevant kinases and BRD4 that phosphorylates other factors as atypical kinases, do the two regulate each other and what is the significance of kinase inhibitors inhibiting the atypical kinase activity of BRD4 in the future treatment of BRD4 related cancer? This evidence concerns the gene BRD4 and cancer.