DUB3 not only stabilizes anti-apoptotic protein MCL1 by deubiquitination, inhibits apoptosis of ovarian cancer cells and drives drug resistance, but also stabilizes oncoproteins (such as CDC25A and Snail) by deubiquitination, promoting breast cancer progression (46, 49), which indicates that inhibition of DUB3 can inhibit the occurrence and invasion of cancer cells. The gene discussed is USP17L2; the disease is breast cancer.