PCAF (P300/CBP-associated factor) is a member of the GCN5 (general control nonderepressible 5)-related N-acetyltransferase family protein acetyltransferases, which not only acetylates histones to promote gene transcription but also acetylates nonhistones to directly promote its transcriptional activity and is involved in coordinating many carcinogenic and tumor suppressive processes, such as cell cycle progression, DNA damage reaction and apoptosis (92–94). This evidence concerns the gene KAT2B and neoplasm.