Further studies have proven that SPOP-mediated BRD4 protein degradation disorder mainly promotes the occurrence of prostate cancer, resists treatment targeting BRD4, and activates the AKT-mTORC1 signaling pathway to regulate tumor cell proliferation, differentiation and apoptosis by increasing the level of BRD4 protein (45). This evidence concerns the gene BRD4 and prostate carcinoma.