Moreover, some studies have demonstrated that TRPV1 suppresses cancer cell proliferation and induces cell death, while TRPV1 overexpression prevents the proliferation of intestinal epithelial HCT116 cells, human pancreatic cancer PANC-1 cells, human skin carcinoma A431 cells and human melanoma A2058 and A375 cells (20–23). Here, TRPV1 is linked to familial pancreatic carcinoma.