Based on the available data from 62 patients (paired white blood cells and tumor samples were sequenced using a panel consisting of 520 cancer-related genes, including 62 cancer susceptibility genes to interrogate germline and somatic alterations, respectively), the analysis revealed that 10 patients carried pathogenic germline mutations (10/62, 16.1%) for BRCA1 (5/62, 8.0%), PALB2 (3/62, 4.8%), MUTYH (1/62, 1.6%) and RAD51C (1/62, 1.6%). The gene discussed is BRCA1; the disease is neoplasm.