identified mutations in TRAF7 (tumor necrosis factor [TNF] receptor–associated factor 7), KLF4 (Kruppel-like factor 4), AKT1 (v-akt murine thymoma viral oncogene homolog 1), and SMO (smoothened) after sequencing a cohort of 300 WHO grade 1 and 2 meningiomas (14). The gene discussed is SMO; the disease is meningioma.