PIK3CA and meningioma: Identification of these non-NF2 driver mutations revealed that the meningioma genomic landscape was more diverse than previously assumed, leading to the identification of additional meningioma driver mutations including POLR2A, SMARCB1 germline variants (including SMARCE1), AKT3, PIK3CA, PIK3R1, PRKAR1A, SUFU, and BAP1 (21, 24, 30–33).