FGFR1 and lung carcinoma: Functional studies revealed that silencing of FGFR1 strongly reduced the viability of the FGFR1-amplified lung cancer cells, inhibited cancer cell growth and clonogenicity, while application of the FGFR inhibitor revealed growth inhibition (p=0.0002) and induced apoptosis (p=0.008) (17, 46).