FGFR1 and non-small cell lung carcinoma: Furthermore, a concurrent amplification of FGFR1 and other genes located in distant loci (on other chromosomes) has been acknowledged in Sq-NSCLC recently (27), specifically the co-amplification of FGFR1 with Defective In Cullin Neddylation 1 Domain Containing 1 gene (DCUN1D1, activation of the focal adhesion kinase and hedgehog signaling pathways) and/or BCL9 Transcription Coactivator gene (BCL9, an alternate activation of Wnt/b-catenin pathway) in the 93% FGFR1-amplified Sq-NSCLC.