FGFR1 and metastatic neoplasm: Also, the majority of Sq-NSCLC cell lines established from primary or metastatic tumors with FGFR1 expression subsequently transfected by a dominant-negative FGFR1 (dnFGFR1) IIIc-green fluorescent protein chimera or treated with FGFR small-molecule inhibitors (SU5402 and PD166866) showed significantly reduced growth, survival, clonogenicity, and migratory potential.