First, we evaluated the expression level of HOXC-AS3 using RNA sequencing data of 169 glioma tissues and 5 normal tissues in The Cancer Genome Atlas (TCGA) (https://portal.gdc.cancer.gov/) and found that HOXC-AS3 expression was markedly increased in GBM tissues compared to that in normal tissues (P < 0.05) (Figure 1A). Here, HOXC-AS3 is linked to central nervous system cancer.