The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR were consistently reduced in cells transfected with sh-FKBP1A, and these ratios were increased by combined treatment with chloroquine (Figure 10D), suggesting that FKBP1A-induced autophagy of HCC cells might or at least partially be mediated by the PI3K/AKT/mTOR pathway. The gene discussed is FKBP1A; the disease is hepatocellular carcinoma.