Unlike the canonical adenoma-carcinoma sequence, SPs are proven to be early precursors to about 15%–30% colorectal carcinoma (CRC) through serrated pathway, frequently associated with BRAF or KRAS oncogenic mutations, microsatellite instability (MSI), and high CpG island methylator phenotype (CIMP) (2). The gene discussed is BRAF; the disease is adenoma.