Li et al. (2016) had studied the pathogenesis mechanism of pigs infected by porcine epidemic diarrhea virus (PEDV) YN13/YN144 by iTRAQ labeling and LC-MS/MS, and identified the differently expressed proteins (DEPs) proposed heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), eukaryotic initiation factor 4G1 (eIF4G1), and heat shock protein (HSP) family could be responsible for the pathogenicity differences in piglets after infection (Li, et al. 2016). Here, HNRNPA1 is linked to infection.