For example, upregulated CRNDE accelerates proliferation and metastasis of CRC cells by regulating Wnt/β-catenin signaling pathways.20, 22 CRNDE also forms a complex with heterogeneous nuclear ribonucleoprotein U like 2 (hnRNPUL2) in the cytoplasm and activates Ras/MAPK signaling pathways, thereby accelerating CRC cell proliferation and migration.19 The gene discussed is HNRNPUL2; the disease is colorectal carcinoma.