CRNDE promotes the progression of leukemic cells in B cell precursor ALL (BCP-ALL), but inhibits the disease progression in CLL.71, 72 Mechanistically, in BCP-ALL, CRNDE targets the miR-345-5p/cyclic AMP response element-binding protein (CREB) axis to promote cell growth.71 Here, CRNDE is linked to acute lymphoblastic leukemia.