CRNDE promotes the progression of leukemic cells in B cell precursor ALL (BCP-ALL), but inhibits the disease progression in CLL.71, 72 Mechanistically, in BCP-ALL, CRNDE targets the miR-345-5p/cyclic AMP response element-binding protein (CREB) axis to promote cell growth.71 The gene discussed is CREB1; the disease is acute lymphoblastic leukemia.