CRNDE binding to EZH2, a core component of the polycomb repressive complex 2 (PRC2), epigenetically inhibits the expression of dual-specificity phosphatase 5 (DUSP5) and cyclin-dependent kinase inhibitor 1A (CDKN1A), thereby promoting CRC development.25 This evidence concerns the gene DUSP5 and colorectal carcinoma.