Using the AKIN criteria in a retrospective analysis, Khalil et al. identified AKI in 13.3% of a series of patients with dengue confirmed by the presence of IgM antibodies, independent of the severity of disease; 64.8% of the patients were in stage 1, 18.3% stage 2, and 16.9% stage 3 of the disease [18] In another study, the RIFLE classification was used to investigate the occurrence of AKI in patients with tropical acute febrile disease. Here, CD40LG is linked to acute kidney injury.