TMBIM6 and ganglioneuroma: Interestingly, knockdown of TMBIM6 eliminated the regulatory effect of GN on mitophagy/mito-fission (Figures 9(a)–9(g)) and blocking effect of GN on mitochondrial apoptosis pathway, which further verified the important role of TMBIM6 in the regulatory mechanism of GN protecting cardiomyocytes.