However, GN can increase the level of mitophagy and mitochondrial biosynthesis (Figures 10(a)–10(e)), and si-TMBIM6 could inhibit the regulation of GN on mitophagy and mitochondrial biosynthesis (Figures 10(a)–10(e)), which further verified the important role of TMBIM6 in the regulatory mechanism of GN protecting cardiomyocytes. The gene discussed is TMBIM6; the disease is ganglioneuroma.