In myofibroblasts, NLRP3 inflammasome activation can cause the increase of activated IL-1β, which ultimately stimulates collagen synthesis, extracellular matrix protein expression, and myofibroblast differentiation, and participates in myocardial fibrosis and scar repair after myocardial infarction [46, 47]. This evidence concerns the gene NLRP3 and myocardial infarction.