The Western blot results verified that the i.t. or i.p. treatment with EGCG improved the spinal protein levels of IGF-1 and p-IGF1R in diabetic mice (Figure 6(e), EGCGi.t. vs. T1DM, P = 0.0023 for IGF-1, P = 0.0011 for p-IGF1R, n = 5; EGCGi.p. vs. T1DM, P = 0.0007 for IGF-1, P = 0.0035 for p-IGF1R). Here, IGF1R is linked to type 1 diabetes mellitus.