Treatment with rIGF-1 did not affect the GFAP immunoreactivity (Figure 5(b), P = 0.8236, n = 5) but reduced the number of Iba-1+ microglia in the SDH of T1DM mice on D14 (Figures 5(c) and 5(d), P = 0.0005, n = 5). This evidence concerns the gene AIF1 and type 1 diabetes mellitus.