Moreover, i.t. or i.p. treatment with EGCG raised the IGF-1+ ratio in Iba-1+ cells (Figures 7(c) and 7(e), P < 0.0001, n = 5) and decreased iNOS+Iba-1+ microglia in the SDH of T1DM mice on D14 (Figures 5(f) and 5(g), P < 0.0001, n = 5). The gene discussed is IGF1; the disease is type 1 diabetes mellitus.