The comparison analysis suggested that compared with control mice, the number of IGF-1+ microglia was markedly less (Figures 2(b)–2(e); T1DM vs. control, 11.07 ± 4.264 vs. 38.92 ± 9.696/mm2, P = 0.0019; n = 4), while a significant difference in IGF-1+ neurons or astrocytes was not observed (Figures 2(b)–2(e); P = 0.4814 for GFAP+, P = 0.0999 for NeuN+; n = 4). This evidence concerns the gene IGF1 and type 1 diabetes mellitus.