IGF1 and type 1 diabetes mellitus: Moreover, the number of IGF-1+ cells in the SDH of T1DM mice extensively decreased on D14 and D21 (Figure 1(e); T1DM-D14 and T1DM-D21 vs. control, 84.07 ± 11.23 and 71.71 ± 12.98 vs. 147.7 ± 28.59/mm2, P < 0.01 & P < 0.001, n = 4).