Sema4D promotes proliferation and inhibits apoptosis in acute leukemia and may be regarded as a potential biomarker for acute leukemia [29]; but it remains unknown whether Sema4D level in peripheral blood is associated with the clinical characteristics in acute leukemia and how Sema4D expression predicts the prognosis in acute leukemia. The gene discussed is SEMA4D; the disease is acute leukemia.