We further examined the expression of CD72 (the receptor of Sema4D in B lymphocytes, T lymphocytes, and myeloid cells) in PBMCs of B-ALL, T-ALL, and AML; its expression increased in B-ALL, T-All, and AML patients compared to healthy children (Supplementary Fig 1a, b and c). The gene discussed is SEMA4D; the disease is acute lymphoblastic leukemia.