On the other hand, more and more effective and potential early biomarkers have been discovered with the in-depth study of AKI pathology, such as neutrophil gelatinase associated lipoprotein (NGAL), γ-glutamyl transpeptidase (GGT), kidney injury molecule-1 (KIM-1), microRNA (miRNA) and excess reactive oxygen species and nitrogen (RONS) 27-30. The gene discussed is LCN2; the disease is acute kidney injury.