Notably, significantly decreased expression of FAO related genes (CPT1α, ACOX1, Ehhadh, Acaa1b, SCAD, LCAD and VLCAD; Figure 3C) was observed in the liver of rAAV-shPRMT1 infected HFD-fed mice as compared to the rAAV-shScramble infected HFD-fed mice, suggesting presumably impaired expression of FAO genes in the liver of rAAV-shPRMT1 infected mice. Here, ACADS is linked to very long chain acyl-CoA dehydrogenase deficiency.