PRMT1 and steatosis: Intriguingly, consistent with the knockdown findings mentioned above, overexpression of PRMT1-WT in liver attenuated the development of HFD-induced steatosis as evident by the lower hepatic lipid accumulation in rAAV-PRMT1-WT infected mice as compared to the rAAV-Luc group (Figure 4C) as well as lower hepatic triglyceride content (Figure 4D).