PRMT1 and fatty liver disease: Then, we provided several lines of in vivo evidence demonstrating the importance of the PRMT1 in alleviating hepatic steatosis by using rAAV mediated tissue-specific gene delivery, including chronic knockdown of hepatic PRMT1 exacerbated hepatic steatosis and liver injury in HFD-fed mice, and chronic overexpression of PRMT1, but not the methyltransferase defective mutant PRMT1G80R in the liver alleviated HFD-induced hepatic steatosis.