INS and Glucose intolerance: Interestingly, although no significant change in fed and fasting blood glucose levels between rAAV-shPRMT1 and rAAV-shScramble infected mice were observed (Figure S2E-F), hepatic PRMT1 knockdown mice exacerbated HFD-induced glucose intolerance as compared to the controls (Figure S2G), while insulin sensitivity was not significantly affected (Figure S2H).