While our findings provide strong evidence supporting a crucial role of the PINCH-1-NEDD4-IGF-1R signaling axis in regulation of skin cancer cell proliferation, survival and tumor growth, they do not rule out the possibility that PINCH-1 may also participate in other signaling pathways that are pertinent to regulation of cancer cell proliferation and survival. The gene discussed is IGF1R; the disease is skin neoplasm.