IGF1R and squamous cell carcinoma: Nevertheless, the fact that depletion of NEDD4 from PINCH-1 deficient squamous carcinoma cells restored to a large extent cell proliferation and survival (Figure 5M-R) strongly argues that the PINCH-1-NEDD4-IGF-1R signaling axis delineated in the current study represents one of the major, if not the only, signaling pathways through which PINCH-1 regulates squamous carcinoma cell proliferation and survival.