Indeed, previous studies by us and others have shown that PINCH-1 can interact with multiple signaling proteins including ILK 37, Nck-2 60, RSU-1 61, 62, EPLIN 50, myoferlin 53 and Notch-2 55, which may also contribute to the regulation of cancer cell proliferation and survival. The gene discussed is NCK2; the disease is cancer.