NEDD4 and neoplasm: Given the structural similarity between the C2 domains of NEDD4 and Smurf1 and the functional importance of NEDD4 C2 domain in interaction with GRB10 and regulation of IGF-1R degradation, we sought to test whether PINCH-1 interacts with NEDD4 C2 domain and if so, its function in regulation of IGF-1R expression and IGF-1R-dependent processes including cell proliferation, survival and tumor growth.