STAT3 and viral infectious disease: Among the top 25 pathways enriched by the 105 differentially expressed genes in response to SARS-CoV-2 infection (Figure 5C, Table S2), 'cytokine-cytokine receptor interaction' was ranked as the top, and JAK/STAT3 signaling, the pathway that mediates cytokine signaling68 was identified as up-regulated upon virus infection (Figure 5C, Figure S6A).