Mice implanted with MDA-MB-231 NTC or A2BR knockdown subclones were treated with 10 mg/kg paclitaxel every 5 days for three doses and tumor samples were collected for ChIP followed by qPCR with primers flanking FOXO3 binding site of NANOG, SOX2 and KLF4 genes. This evidence concerns the gene FOXO3 and neoplasm.