SPP1 and retinitis pigmentosa: Subretinal microglia in the light damage model of acute photoreceptor degeneration and the RhoP23H/WT model of retinitis pigmentosa have been shown to have overlapping expression signatures with DAM, including upregulation of Cd68, Axl, Tyrob, Apoe, Spp1 and Trem2 and downregulation of Tmem119, P2ry12, Cx3cr1, and Siglech 5.