For example, Jin et al. revealed that methyltransferase like 3 (METTL3) facilitated expression and activity of Yes-associated protein (YAP), inducing drug resistance and metastasis of NSCLC [12], whereas ALKBH5 repressed the expression of YT521-B homology domain-containing family (YTHDF)-mediated YAP and inhibited the activity of miR-107/LATS2-mediated YAP, thus suppressing the growth and metastasis of lung tumors [13]. This evidence concerns the gene METTL3 and non-small cell lung carcinoma.