EPHX3 and cancer: To understand the regulatory role of EPHX3 in cancer, we first examined its expression in 33 human cancer types on TCGA and found that EPHX3 is highly expressed in CESC, CHOL, COAD, GBM, LUAD, PCPG, READ, and THCA but poorly expressed in HNSC, BRCA, ESCA, KICH, KIRC, KIRP, and PRAD (Figure 1(a)).