This analysis revealed that EPHX3 expression negatively correlated with T-cell CD8+ naïve (NCAM1), T-cell CD4+ TH1 (CD25), monocytes (CD14), macrophages (CD163, VSIG4, MS4A4A), endothelial cells (CDH5), and T-cell NK (CD56, FCGR3A) in HNSCC (Table 1). This evidence concerns the gene VSIG4 and head and neck squamous cell carcinoma.