In order to explore the relationship between the expression characteristics of miRNA in chronic lymphoblastic leukemia (CLL) and known prognostic factors, Crespo et al. studied 56 patients with CLL and found that there was little or no mutation in IgVH gene, that is, those with high expression of ZAP-70 protein had high invasiveness and low survival rate [21]. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.