Compared with normal samples, genes with CNV amplification exhibited a remarkedly higher expression in BC samples, such as CD7, IDO1, and LYZ, while other genes with deleted CNV, such as INPP5D, were significantly decreased in tumor tissues (Figures 3B,D), indicating that there was high heterogeneity between the genomic and transcriptomic landscape of TME-related signature genes and this expression imbalance played an essential role in BC tumorigenesis and progression. The gene discussed is IDO1; the disease is breast cancer.