CD4 and neoplasm: The correlation matrix revealed that the TME-score positively correlated with tumor-infiltrating lymphocytes, including activated CD4+/CD8+ T cells, activated B cells, nature killer T cells, and macrophages M1, and negatively correlated with T cells regulatory, tumor-associated neutrophils, and macrophages M2, demonstrating the crosstalk between TME-score and tumor-infiltrating immune cells (Figure 6C).