To explore whether the above genetic variation affected transcriptomic expression, we calculated the differences in gene expression value between BC and normal samples and observed that HLA-DRA, HLA-DPB1, and SPP1 were significantly increased in BC tissues, while, FABP4, PLIN1, and APOD were markedly downregulated in tumor tissues (Figure 3D, Supplementary Table S3). This evidence concerns the gene APOD and neoplasm.