CD4 and neoplasm: Further analysis of the TME feature via CIBERSORT revealed that compared with gene cluster I, cluster II had elevated infiltration of antitumor immune cells, such as NK cells activated, T cells CD4 memory activated/CD8, and macrophages M1, and a decreased proportion of immunosuppressive or tumor-promoting immune cells, such as macrophages M2 and Treg cells (Figure 5C).